Publication: Molecular basis of β<sup>o</sup>-thalassemia/HbE disease in Thailand
3
Issued Date
1989-07-31
Resource Type
ISSN
10902104
0006291X
0006291X
Other identifier(s)
2-s2.0-0024315888
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biochemical and Biophysical Research Communications. Vol.162, No.2 (1989), 846-851
Suggested Citation
Songsak Petmitr, Prapon Wilairat, Jiraporn Kownkon, Pranee Winichagoon, Suthat Fucharoen Molecular basis of β<sup>o</sup>-thalassemia/HbE disease in Thailand. Biochemical and Biophysical Research Communications. Vol.162, No.2 (1989), 846-851. doi:10.1016/0006-291X(89)92387-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15707
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Title
Molecular basis of β<sup>o</sup>-thalassemia/HbE disease in Thailand
Other Contributor(s)
Abstract
The molecular basis of β o -thalassemia/HbE disease in 30 Thai patients was investigated using DNA amplification and dot-blot hybridization with a number of allele specific oligonucleotide probes. The mutations identified were 17 cases of 4 base-pair deletion at codons 41-42, 4 cases of amber mutation at codon 17, and one case each of an ochre mutation at codon 35, a single base substitution at position 5 of IVS-1, and a single base substitution at position 654 of IVS-2. © 1989.