Publication:
The aspergillus fumigatus p-type golgi apparatus Ca2+/Mn2+ ATPase pmra is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis

Issued Date

2010-03-01

Resource Type

Note

ISSN

15359778

DOI

10.1128/EC.00378-09

Other identifier(s)

2-s2.0-77649288776

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Eukaryotic Cell. Vol.9, No.3 (2010), 472-476

Suggested Citation

Nadthanan Pinchai, Praveen Rao Juvvadi, Jarrod R. Fortwendel, B. Zachary Perfect, Luise E. Rogg, Yohannes G. Asfaw, William J. Steinbach The aspergillus fumigatus p-type golgi apparatus Ca2+/Mn2+ ATPase pmra is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis. Eukaryotic Cell. Vol.9, No.3 (2010), 472-476. doi:10.1128/EC.00378-09 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28774

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Title

The aspergillus fumigatus p-type golgi apparatus Ca2+/Mn2+ ATPase pmra is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis

Author(s)

Nadthanan Pinchai
 Praveen Rao Juvvadi
 Jarrod R. Fortwendel
 B. Zachary Perfect
 Luise E. Rogg
 Yohannes G. Asfaw
 William J. Steinbach

Other Contributor(s)

Duke University School of Medicine
 Mahidol University

Abstract

The Aspergillus fumigatus δpmrA (Golgi apparatus Ca2+/Mn2+ P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased β-glucan and chitin content, it is hypersensitive to cell wall inhibitors but remains virulent, suggesting a role for PmrA in cation homeostasis and cell wall integrity. © 2010, American Society for Microbiology. All Rights Reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Immunology and Microbiology

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URI

https://repository.li.mahidol.ac.th/handle/123456789/28774

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Scopus 2006-2010