Publication:
Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

4

Issued Date

2021-04-15

Resource Type

Article

ISSN

10974172
00928674

DOI

10.1016/j.cell.2021.02.033

Other identifier(s)

2-s2.0-85103055410

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Cell. Vol.184, No.8 (2021), 2201-2211.e7

Suggested Citation

Piyada Supasa, Daming Zhou, Wanwisa Dejnirattisai, Chang Liu, Alexander J. Mentzer, Helen M. Ginn, Yuguang Zhao, Helen M.E. Duyvesteyn, Rungtiwa Nutalai, Aekkachai Tuekprakhon, Beibei Wang, Guido C. Paesen, Jose Slon-Campos, César López-Camacho, Bassam Hallis, Naomi Coombes, Kevin R. Bewley, Sue Charlton, Thomas S. Walter, Eleanor Barnes, Susanna J. Dunachie, Donal Skelly, Sheila F. Lumley, Natalie Baker, Imam Shaik, Holly E. Humphries, Kerry Godwin, Nick Gent, Alex Sienkiewicz, Christina Dold, Robert Levin, Tao Dong, Andrew J. Pollard, Julian C. Knight, Paul Klenerman, Derrick Crook, Teresa Lambe, Elizabeth Clutterbuck, Sagida Bibi, Amy Flaxman, Mustapha Bittaye, Sandra Belij-Rammerstorfer, Sarah Gilbert, David R. Hall, Mark A. Williams, Neil G. Paterson, William James, Miles W. Carroll, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I. Stuart, Gavin R. Screaton Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera. Cell. Vol.184, No.8 (2021), 2201-2211.e7. doi:10.1016/j.cell.2021.02.033 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76208

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Title

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

Author(s)

Piyada Supasa
 Daming Zhou
 Wanwisa Dejnirattisai
 Chang Liu
 Alexander J. Mentzer
 Helen M. Ginn
 Yuguang Zhao
 Helen M.E. Duyvesteyn
 Rungtiwa Nutalai
 Aekkachai Tuekprakhon
 Beibei Wang
 Guido C. Paesen
 Jose Slon-Campos
 César López-Camacho
 Bassam Hallis
 Naomi Coombes
 Kevin R. Bewley
 Sue Charlton
 Thomas S. Walter
 Eleanor Barnes
 Susanna J. Dunachie
 Donal Skelly
 Sheila F. Lumley
 Natalie Baker
 Imam Shaik
 Holly E. Humphries
 Kerry Godwin
 Nick Gent
 Alex Sienkiewicz
 Christina Dold
 Robert Levin
 Tao Dong
 Andrew J. Pollard
 Julian C. Knight
 Paul Klenerman
 Derrick Crook
 Teresa Lambe
 Elizabeth Clutterbuck
 Sagida Bibi
 Amy Flaxman
 Mustapha Bittaye
 Sandra Belij-Rammerstorfer
 Sarah Gilbert
 David R. Hall
 Mark A. Williams
 Neil G. Paterson
 William James
 Miles W. Carroll
 Elizabeth E. Fry
 Juthathip Mongkolsapaya
 Jingshan Ren
 David I. Stuart
 Gavin R. Screaton

Other Contributor(s)

Mahidol Oxford Tropical Medicine Research Unit
 NIHR Oxford Biomedical Research Centre
 Oxford University Hospitals NHS Foundation Trust
 Public Health England
 Diamond Light Source
 Worthing Hospital
 University of Oxford
 Sir William Dunn School of Pathology
 Faculty of Medicine Siriraj Hospital, Mahidol University
 Nuffield Department of Medicine
 University of Oxford Medical Sciences Division
 Instruct-ERIC

Abstract

SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike. The scale of the pandemic and error-prone virus replication is leading to the appearance of mutant viruses and potentially escape from antibody responses. Variant B.1.1.7, now dominant in the UK, with increased transmission, harbors 9 amino acid changes in the spike, including N501Y in the ACE2 interacting surface. We examine the ability of B.1.1.7 to evade antibody responses elicited by natural SARS-CoV-2 infection or vaccination. We map the impact of N501Y by structure/function analysis of a large panel of well-characterized monoclonal antibodies. B.1.1.7 is harder to neutralize than parental virus, compromising neutralization by some members of a major class of public antibodies through light-chain contacts with residue 501. However, widespread escape from monoclonal antibodies or antibody responses generated by natural infection or vaccination was not observed.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/76208

Collections

Scopus 2021