Publication: Quinine and quinidine: A comparison of EKG effects during the treatment of malaria
Issued Date
1983-01-01
Resource Type
ISSN
15334023
01602446
01602446
Other identifier(s)
2-s2.0-0020678283
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Cardiovascular Pharmacology. Vol.5, No.2 (1983), 173-175
Suggested Citation
Nicholas J. White, Sornchai Looareesuwan, David A. Warrell Quinine and quinidine: A comparison of EKG effects during the treatment of malaria. Journal of Cardiovascular Pharmacology. Vol.5, No.2 (1983), 173-175. doi:10.1097/00005344-198303000-00001 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30541
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Title
Quinine and quinidine: A comparison of EKG effects during the treatment of malaria
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Abstract
We recorded electrocardiograms from 31 patients receiving quinine and 14 patients receiving quinidine for the treatment of Plasmodium falciparum malaria. Despite plasma quinine concentrations of up to 20 mg/L, there was no evidence of cardiotoxicity. QT prolongation was considerably greater in the quinidine-treated patients. The mean ratio of change in corrected QT interval to change in plasma concentration (ΔQTc%/ΔCo) was 3.2%·mg-1·L1for quinidine, compared to 0.74%·mg-1·L1for quinine (p < 0.001). T-wave flattening was observed in both groups. Plasma concentrations of quinine cannot be predicted from the EKG, because concentrations within the therapeutic range produced only minor and unpredictable abnormalities. © 1983 Raven Press, New York.