Isolation of 3-(Hydroxyacetyl)indole and Indole-3-carboxylic acid from Red Alga Halymenia durvillei : Their Anti-lung Cancer Cell and in vivo Anti-aging Activity

Abstract

This study aimed to evaluate the bioactivity and phytochemical investigation in red algae Halymenia durvillei. The polarity based solvent partition (hexane, ethyl acetate, butanol and water) of H. durvillei ethanolic crude were used for characterization. The present results of the ethyl acetate extract of red alga H. durvillei generated a 3-(hydroxyacetyl)indole (1), indole-3-carboxylic acid (2) as well as two fatty acids viz. palmitic acid (3) and α-linoleic acid (4). The viability against lung cancer cells of compounds 1 and 2 showed moderate activities against the A549 cell line with inhibition percentages of 12.97% and 25.81%, respectively. Analysis of the dose response of C. elegans anti-aging assay indicated that the survival rate of compound 1 was 12.62% while it was 11.04% for compound 2. Furthermore, H. durvillei isolation was used as an antioxidant, anti-cancer cell and anti-aging resource.