Publication: Encapsulated neem extract containing Azadiractin-A within hydrolyzed poly(vinyl acetate) for controlling its release and photodegradation stability
Issued Date
2009-10-15
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ISSN
13858947
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2-s2.0-67649884555
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Mahidol University
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SCOPUS
Bibliographic Citation
Chemical Engineering Journal. Vol.152, No.2-3 (2009), 591-597
Suggested Citation
Sa A. Riyajan, Jitladda T. Sakdapipanich Encapsulated neem extract containing Azadiractin-A within hydrolyzed poly(vinyl acetate) for controlling its release and photodegradation stability. Chemical Engineering Journal. Vol.152, No.2-3 (2009), 591-597. doi:10.1016/j.cej.2009.05.017 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/27377
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Title
Encapsulated neem extract containing Azadiractin-A within hydrolyzed poly(vinyl acetate) for controlling its release and photodegradation stability
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Abstract
Neem extract containing Azadiractin-A (neem Aza-A), encased in microcapsules, in a matrix of partially hydrolyzed poly(vinyl acetate) crosslinked with glutaralaldehyde 5% (w/v) and 0.05% hydrochloric acid was prepared via a spray drying technique. The photostabilization of unencapsulated and encapsulated neem Aza-A when exposed to ultraviolet light was evaluated. Neem Aza-A solutions and neem Aza-A microcapsules were applied onto the surface of glass slides. At particular intervals, the remaining concentration of neem Aza-A was measured by HPLC. When the ratio of 87% hydrolyzed poly(vinyl acetate) to water was 1:40 this produced the highest concentration of neem Aza-A after exposure to UV. The degree of swelling ratio of microcapsule depended on the crosslinking density and the crystalline content. The neem Aza-A release was measured in water at 25 °C and the effects of different matrices and other parameters such as polymer-water ratios and particle size were studied. The release mechanism of the neem Aza-A from the microspheres was also investigated. © 2009 Elsevier B.V. All rights reserved.