Publication: Performance evaluation of bilayer oxidized regenerated cellulose/poly ε-caprolactone knitted fabric-reinforced composites for dural substitution
Issued Date
2020-01-01
Resource Type
ISSN
20413033
09544119
09544119
Other identifier(s)
2-s2.0-85085050518
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Mahidol University
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SCOPUS
Bibliographic Citation
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. (2020)
Suggested Citation
Ruedee Hemstapat, Waraporn Suvannapruk, Faungchat Thammarakcharoen, Sorayouth Chumnanvej, Jintamai Suwanprateeb Performance evaluation of bilayer oxidized regenerated cellulose/poly ε-caprolactone knitted fabric-reinforced composites for dural substitution. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. (2020). doi:10.1177/0954411920926071 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/56185
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Title
Performance evaluation of bilayer oxidized regenerated cellulose/poly ε-caprolactone knitted fabric-reinforced composites for dural substitution
Abstract
© IMechE 2020. Ideally, alloplastic dural substitute should have functional properties resembling human dura mater and retain a watertight closure to prevent cerebrospinal leakage. Therefore, functional properties for successful dural closure application of newly developed bilayer oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composites were studied and compared with human cadaveric dura mater and three commercial dural substitutes including two collagen matrices and one synthetic poly-L-lactide patch. It was found that oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composites uniquely contained a bilayer structure consisting of micropores distributed within the relatively dense microstructure. Density, tensile properties and stitch tear strength of oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composites were found to be closed to human cadaveric dura mater than those of dense-type and porous-type dural substitutes. Water tightness performance in both sutured and non-sutured forms of oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composites was slightly inferior to human cadaveric dura mater, but still better than those of commercial dural substitutes. This study revealed that oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composite showed better functional properties than typical dural substitutes and was found to be a good candidate for being employed as a dural substitute. The role and relationship of both microstructure and the type of materials on the functional properties and water tightness of the dural substitutes were also elucidated.