Publication: Heterogenity of Echinococcus canadensis genotype 6 − the main causative agent of cystic echinococcosis in Birjand, Eastern Iran
Issued Date
2017-10-15
Resource Type
ISSN
18732550
03044017
03044017
Other identifier(s)
2-s2.0-85028539977
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Mahidol University
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SCOPUS
Bibliographic Citation
Veterinary Parasitology. Vol.245, (2017), 78-85
Suggested Citation
Mehdi Karamian, Fatemeh Haghighi, Mina Hemmati, Walter Robert Taylor, Alireza Salehabadi, Mohammad Amin Ghatee Heterogenity of Echinococcus canadensis genotype 6 − the main causative agent of cystic echinococcosis in Birjand, Eastern Iran. Veterinary Parasitology. Vol.245, (2017), 78-85. doi:10.1016/j.vetpar.2017.08.018 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/42744
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Title
Heterogenity of Echinococcus canadensis genotype 6 − the main causative agent of cystic echinococcosis in Birjand, Eastern Iran
Abstract
© 2017 Elsevier B.V. Little is known about the genotypes of Echinococcus spp. and their life cycles in eastern Iran. We analysed the partial sequences of the nad1 and cox1 genes from 17 isolates from hydatid cyst-infected patients (n = 9), camels (n = 5) and sheep (n = 3) in Birjand, eastern Iran. A new primer pair was also used to amplify the long fragment (1180 bp) of the cox1 gene. All camel and eight human isolates were G6 strains of Echinococcus canadensis while one human isolate and the three sheep isolates were G1 genotypes (sheep strain) of E. granulosus sensu stricto (s.s.). Nad1 and cox1 sequence analyses showed high G6 genetic homogeneity, similar to previously reported G6 strains from southeast and central Iran, Sudan and Mauritania. Low nucleotide and haplotype diversity similar to G6 strains from Russia (Altai republic) and Kazakhstan was also found, consistent with a bottleneck effect. In this study, G6 was the most common Echinococcus genotype. Genetic homogeneity of east, southeast and central Iranian G6 and its low genetic diversity may be due limited mobility and contact between humans and camels from other regions because of large, inhospitable deserts.