Publication: Parasite multiplication potential and the severity of falciparum malaria
3
Issued Date
2000-04-19
Resource Type
ISSN
00221899
DOI
Other identifier(s)
2-s2.0-0034074265
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.181, No.3 (2000), 1206-1209
Suggested Citation
Kesinee Chotivanich, Rachanee Udomsangpetch, Julie A. Simpson, Paul Newton, Sasithon Pukrittayakamee, Sornchai Looareesuwan, Nicholas J. White Parasite multiplication potential and the severity of falciparum malaria. Journal of Infectious Diseases. Vol.181, No.3 (2000), 1206-1209. doi:10.1086/315353 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26256
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Title
Parasite multiplication potential and the severity of falciparum malaria
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Abstract
The multiplication rates and invasiveness of Plasmodium falciparum parasites isolated from adult Thai patients hospitalized with uncomplicated malaria (n = 34) were compared with those from persons with severe malaria (n = 42). To simulate severe malaria and control for host effects, the in vitro cultures were adjusted to 1% parasitemia and used the same red blood cell donor. E falciparum isolates from persons with severe malaria had initial cycle multiplication rates in vitro that were 3-fold higher than those from uncomplicated malaria (median [95% confidence interval], 8.3 [7.1-10.5] vs. 2.8 [1.7-3.9]; P = .001). Parasites causing severe malaria exhibited unrestricted red blood cell invasion, whereas those from uncomplicated malaria were restricted to a geometric mean of 40 (31%-53%) of red blood cells. E falciparum parasites causing severe malaria were less selective and multiplied more at high parasitemias than those causing uncomplicated malaria.