Publication: Polymorphisms in fas gene is associated with HIV-related lipoatrophy in thai patients
Issued Date
2013-01-01
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ISSN
19318405
08892229
08892229
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2-s2.0-84871905413
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Mahidol University
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SCOPUS
Bibliographic Citation
AIDS Research and Human Retroviruses. Vol.29, No.1 (2013), 142-150
Suggested Citation
Sirirat Likanonsakul, Tippawan Rattanatham, Siriluk Feangvad, Sumonmal Uttayamakul, Wisit Prasithsirikul, Somkid Srisopha, Ravee Nitiyanontakij, Pimrapat Tengtrakulcharoen, MacIej Tarkowski, Agostino Riva, Emi E. Nakayama, Tatsuo Shioda Polymorphisms in fas gene is associated with HIV-related lipoatrophy in thai patients. AIDS Research and Human Retroviruses. Vol.29, No.1 (2013), 142-150. doi:10.1089/aid.2012.0114 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/31991
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Title
Polymorphisms in fas gene is associated with HIV-related lipoatrophy in thai patients
Abstract
The present study aimed to evaluate the role of genetic polymorphisms in the emergence of lipoatrophy or lipodystrophy in HIV-infected patients with antiretroviral therapy (ART) in Thailand. Position 455 upstream of the Apolipoprotein C3 gene (ApoC3 T-455C, rs2854116), codon 64 of the Beta3 adrenergic receptor gene (ARβ3 Tcod64C, rs4994), and position 670 upstream of the Fas gene (Fas A-670G, rs1800682) were genotyped in 829 HIV-infected Thai patients who had started ART. Crude and adjusted incidence rate ratios (IRR) were calculated using Poisson regression. The serum levels of cholesterol, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were also analyzed. Multivariate analysis revealed an association between the Fas -670AA genotype, but not the ApoC3 -455 or ARβ3 cod64 genotypes, with the incidence of lipoatrophy after adjusting for gender and stavudine (d4T)-containing regimens (IRR=1.72, 95% CI=1.20-2.45, p=0.003). However, ApoC3 -455C homozygous patients showed elevated serum levels of triglycerides, while this genotype did not affect serum total cholesterol, HDL, or LDL levels in patients with lipoatrophy or lipodystrophy. In contrast, the ARβ3 cod64 genotype did not show any significant association with the serum levels of cholesterol, triglycerides, HDL, or LDL. In conclusion, Fas -670AA affected the incidence of lipoatrophy in HIV-1-infected Thai patients, while the ApoC3 -455C allele affected the serum levels of triglycerides. These results confirmed the role of genetics in the development of ART-related metabolic disorders. © Copyright 2013, Mary Ann Liebert, Inc. 2013.