Publication: Genotypic analysis of plasmid-mediated β-lactamases amongst Enterobacteriaceae other than Escherichia spp. and Klebsiella spp. that are non-susceptible to a broad-spectrum cephalosporin
Issued Date
2010-10-01
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ISSN
09248579
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2-s2.0-77955923359
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Antimicrobial Agents. Vol.36, No.4 (2010), 343-347
Suggested Citation
Pattarachai Kiratisin, Arunocha Henprasert Genotypic analysis of plasmid-mediated β-lactamases amongst Enterobacteriaceae other than Escherichia spp. and Klebsiella spp. that are non-susceptible to a broad-spectrum cephalosporin. International Journal of Antimicrobial Agents. Vol.36, No.4 (2010), 343-347. doi:10.1016/j.ijantimicag.2010.06.029 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/29504
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Title
Genotypic analysis of plasmid-mediated β-lactamases amongst Enterobacteriaceae other than Escherichia spp. and Klebsiella spp. that are non-susceptible to a broad-spectrum cephalosporin
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Abstract
Enterobacteriaceae other than Escherichia spp. and Klebsiella spp. are recognisable for their increasing resistance. Plasmid-mediated β-lactamases, including extended-spectrum β-lactamases (ESBLs), plasmid-mediated AmpC β-lactamases (pAmpCs) and the newly emerged KPC, play an important role in β-lactam resistance. In this study, we investigated the genetic characteristics of plasmid-mediated β-lactamases amongst non-Escherichia, non-Klebsiella Enterobacteriaceae that were non-susceptible to at least a broad-spectrum cephalosporin. A total of 143 (23.9%) of 598 isolates during the 6-month study period met the screening criteria, amongst which 142 (99.3%) and 99 (69.2%) isolates carried ESBL and pAmpC genes, respectively. Resistance genotypes were described. blaKPCwas not detected in isolates with reduced susceptibility to carbapenems. This study provides an insight into plasmid-mediated resistance determinants amongst cephalosporin-non-susceptible Enterobacteriaceae other than Escherichia spp. and Klebsiella spp. © 2010 Elsevier B.V. and the International Society of Chemotherapy.