Publication: Endemic primary distal renal tubular acidosis in Thailand
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Issued Date
1990-01-01
Resource Type
ISSN
14602393
14602725
14602725
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2-s2.0-0025274931
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Mahidol University
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SCOPUS
Bibliographic Citation
QJM. Vol.74, No.3 (1990), 289-301
Suggested Citation
Sanga Nilwarangkur, Sumalee Nimmannit, Vipada Chaovakul, Watanachai Susaengrat, Somphong Ong-Aj-Yooth, Somkiat Vasuvattakul, Phannee Pidetcha, Prida Malasit Endemic primary distal renal tubular acidosis in Thailand. QJM. Vol.74, No.3 (1990), 289-301. doi:10.1093/oxfordjournals.qjmed.a068437 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/16154
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Title
Endemic primary distal renal tubular acidosis in Thailand
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Abstract
Within a period of 3 years, 103 patients with primary type I distal renal tubular acidosis were reported from two hospitals in the northeast of Thailand, with cases peaking in the summer. The patients' age ranged from 18 to 76 with a mean and mode of 39 and 47 years, respectively. The female to male ra tio was 3.3:1. All patients presented with generalized muscle weakness and bone pain and nocturia were frequent manifestations. Hypokalaemia and hyperchloraemic metabolic acidosis were constant findings and were more pronounced in patients with roentgenographic evidence of nephrocalcinosis and osteomalacia. Urinary citrate was extremely low in most of the patients. Nephrocalcinosis and/or renal stones were present in 27.2% of the patients and osteomalacia was found in 23.3%. All patients were Lao-Thai. This is the first report of a large group of patients with distal renal tubular acidosis, endemic within a particular geographical region. © Oxford University Press 1990.