Publication: PATHOPHYSIOLOGICAL AND PROGNOSTIC SIGNIFICANCE OF CEREBROSPINAL-FLUID LACTATE IN CEREBRAL MALARIA
Issued Date
1985-04-06
Resource Type
ISSN
01406736
Other identifier(s)
2-s2.0-0021955002
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Mahidol University
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SCOPUS
Bibliographic Citation
The Lancet. Vol.325, No.8432 (1985), 776-778
Suggested Citation
Nicholas J. White, Sornchai Looareesuwan, Rodney E. Phillips, David A. Warrell, Pornthep Chanthavanich, Praneet Pongpaew PATHOPHYSIOLOGICAL AND PROGNOSTIC SIGNIFICANCE OF CEREBROSPINAL-FLUID LACTATE IN CEREBRAL MALARIA. The Lancet. Vol.325, No.8432 (1985), 776-778. doi:10.1016/S0140-6736(85)91445-X Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30870
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Title
PATHOPHYSIOLOGICAL AND PROGNOSTIC SIGNIFICANCE OF CEREBROSPINAL-FLUID LACTATE IN CEREBRAL MALARIA
Abstract
Cerebrospinal-fluid (CSF) lactate concentrations were elevated in all but 1 of 45 patients with cerebral malaria. They were significantly higher in patients who died (9·0±5·3 mmol/l, mean±SD) than in survivors (3·4±1·1 mmol/l, p=0·0002) and had returned to normal values in each of 9 patients studied after recovery of consciousness. There was a significant negative correlation between CSF lactate and CSF glucose. All 11 patients with CSF lactate concentrations above 6 mmol/l died. CSF lactate is thus an important prognostic indicator in cerebral malaria and these findings suggest that hypoxia contributes to the pathogenesis of this disorder. © 1985.