Publication: Preoperative serum albumin is associated with intra-abdominal infection following major hepatectomy
Issued Date
2019-11-01
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18686982
18686974
18686974
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2-s2.0-85074113055
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Hepato-Biliary-Pancreatic Sciences. Vol.26, No.11 (2019), 479-489
Suggested Citation
Narongsak Rungsakulkij, Watoo Vassanasiri, Pongsatorn Tangtawee, Wikran Suragul, Paramin Muangkaew, Somkit Mingphruedhi, Suraida Aeesoa Preoperative serum albumin is associated with intra-abdominal infection following major hepatectomy. Journal of Hepato-Biliary-Pancreatic Sciences. Vol.26, No.11 (2019), 479-489. doi:10.1002/jhbp.673 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51323
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Title
Preoperative serum albumin is associated with intra-abdominal infection following major hepatectomy
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Abstract
© 2019 The Authors. Journal of Hepato-Biliary-Pancreatic Sciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Hepato-Biliary-Pancreatic Surgery. Background: Major hepatectomy is a complex surgical procedure with high morbidity. Intra-abdominal infection (IAI) is common following hepatectomy and affects treatment outcomes. This study was performed to investigate perioperative factors and determine whether the preoperative serum albumin level is associated with IAI following major hepatectomy. Methods: From January 2008 to December 2018, 268 patients underwent major hepatectomy. We retrospectively analyzed demographic data and preoperative and perioperative variables. IAI was defined as organ/space surgical site infection. Risk factors for IAI were analyzed by logistic regression analysis. Results: In total, 268 patients were evaluated. IAI was observed in 38 patients (14.6%). The mortality rate in the IAI group was 15.7%. Multivariate logistic analysis confirmed that the serum albumin level (odds ratio 0.91; 95% confidence interval 0.84–0.97; P = 0.03) and operative duration (odds ratio 1.50; 95% confidence interval 1.18–1.91; P < 0.01) were independent factors associated with IAI. A logistic model using the serum albumin level and operative duration to estimate the probability of IAI was analyzed. The area under the receiver operating characteristic curve for predicting IAI was 0.78. Conclusion: The serum albumin level and operative duration were independent factors predicting IAI following major hepatectomy.