Publication: Modification of platelet shape change parameter by modified phospholipids in oxidized LDL
Issued Date
2009-02-01
Resource Type
ISSN
01252208
01252208
01252208
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2-s2.0-61449241739
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.92, No.2 (2009), 229-235
Suggested Citation
Werasak Sutipornpalangkul, Supeenun Unchen, Yupin Sanvarinda, Udom Chantharaksri Modification of platelet shape change parameter by modified phospholipids in oxidized LDL. Journal of the Medical Association of Thailand. Vol.92, No.2 (2009), 229-235. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28197
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Title
Modification of platelet shape change parameter by modified phospholipids in oxidized LDL
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Abstract
Background: It is believed that the oxidatively modified lipoproteins play a critical role in activating platelets and is a contributing factor in the etiology of a number of cardiovascular-related diseases. Objective: Identify the active component(s) of oxidized LDL that initiated shape change in plasma-free human platelets prepared by a gel filtration method. Material and Method: Shape change parameter of platelets was monitored following exposure platelets to LDL, copper sulfate-oxidized LDL, and different types of lipids extracted of the corresponding LDL. Results: Oxidized LDL, but not native LDL, increased the shape-change parameter in a concentration-dependent manner. Specifically, phosphatidyl serine from oxidized LDL was responsible for this effect. Conclusion: Oxidized phospholipids generated during the oxidative modification of LDL are likely to be the active components responsible for changes in platelet function.