Publication: Japanese encephalitis virus remains an important cause of encephalitis in Thailand
Issued Date
2010-10-01
Resource Type
ISSN
12019712
Other identifier(s)
2-s2.0-77957750468
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Infectious Diseases. Vol.14, No.10 (2010)
Suggested Citation
Sonja J. Olsen, Krongkaew Supawat, Angela P. Campbell, Surapee Anantapreecha, Sahas Liamsuwan, Supoch Tunlayadechanont, Anannit Visudtibhan, Somsak Lupthikulthum, Kanlaya Dhiravibulya, Akravudh Viriyavejakul, Punnee Vasiknanonte, Kiatsak Rajborirug, Veerachai Watanaveeradej, Chacrin Nabangchang, Janeen Laven, Olga Kosoy, Amanda Panella, Christine Ellis, Sununta Henchaichon, Nino Khetsuriani, Ann M. Powers, Scott F. Dowell, Marc Fischer Japanese encephalitis virus remains an important cause of encephalitis in Thailand. International Journal of Infectious Diseases. Vol.14, No.10 (2010). doi:10.1016/j.ijid.2010.03.022 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29528
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Title
Japanese encephalitis virus remains an important cause of encephalitis in Thailand
Author(s)
Sonja J. Olsen
Krongkaew Supawat
Angela P. Campbell
Surapee Anantapreecha
Sahas Liamsuwan
Supoch Tunlayadechanont
Anannit Visudtibhan
Somsak Lupthikulthum
Kanlaya Dhiravibulya
Akravudh Viriyavejakul
Punnee Vasiknanonte
Kiatsak Rajborirug
Veerachai Watanaveeradej
Chacrin Nabangchang
Janeen Laven
Olga Kosoy
Amanda Panella
Christine Ellis
Sununta Henchaichon
Nino Khetsuriani
Ann M. Powers
Scott F. Dowell
Marc Fischer
Krongkaew Supawat
Angela P. Campbell
Surapee Anantapreecha
Sahas Liamsuwan
Supoch Tunlayadechanont
Anannit Visudtibhan
Somsak Lupthikulthum
Kanlaya Dhiravibulya
Akravudh Viriyavejakul
Punnee Vasiknanonte
Kiatsak Rajborirug
Veerachai Watanaveeradej
Chacrin Nabangchang
Janeen Laven
Olga Kosoy
Amanda Panella
Christine Ellis
Sununta Henchaichon
Nino Khetsuriani
Ann M. Powers
Scott F. Dowell
Marc Fischer
Other Contributor(s)
Centers for Disease Control and Prevention
Thailand Ministry of Public Health
Viral and Rickettsial Zoonoses Br.
Queen Sirikit National Institute of Child Health
Mahidol University
Rajavithi Hospital
Prasat Neurological Institute
Prince of Songkla University
Hatyai Hospital
Phramongkutklao College of Medicine
National Center for Emerging and Zoonotic Infectious Diseases
Thailand Ministry of Public Health
Viral and Rickettsial Zoonoses Br.
Queen Sirikit National Institute of Child Health
Mahidol University
Rajavithi Hospital
Prasat Neurological Institute
Prince of Songkla University
Hatyai Hospital
Phramongkutklao College of Medicine
National Center for Emerging and Zoonotic Infectious Diseases
Abstract
Background: Japanese encephalitis virus (JEV) is endemic in Thailand and prevention strategies include vaccination, vector control, and health education. Methods: Between July 2003 and August 2005, we conducted hospital-based surveillance for encephalitis at seven hospitals in Bangkok and Hat Yai. Serum and cerebrospinal (CSF) specimens were tested for evidence of recent JEV infection by immunoglobulin M (IgM) enzyme-linked immunosorbent assay (ELISA) and a plaque reduction neutralization test (PRNT). Results: Of the 147 patients enrolled and tested, 24 (16%) had evidence of acute flavivirus infection: 22 (15%) with JEV and two (1%) with dengue virus. Of the 22 Japanese encephalitis (JE) cases, 10 (46%) were aged ≤15 years. The median length of hospital stay was 13 days; one 13-year-old child died. Ten percent of encephalitis patients enrolled in Bangkok hospitals were found to have JEV infection compared to 28% of patients enrolled in hospitals in southern Thailand (p< 0.01). Four (40%) of the 10 children with JE were reported as being vaccinated. Conclusions: JEV remains an important cause of encephalitis among hospitalized patients in Thailand. The high proportion of JE among encephalitis cases is concerning and additional public health prevention efforts or expanded vaccination may be needed. © 2010.