Publication: Cold urticaria – What we know and what we do not know
Issued Date
2021-04-01
Resource Type
ISSN
13989995
01054538
01054538
Other identifier(s)
2-s2.0-85097986622
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Allergy: European Journal of Allergy and Clinical Immunology. Vol.76, No.4 (2021), 1077-1094
Suggested Citation
Natalya Maltseva, Elena Borzova, Daria Fomina, Mojca Bizjak, Dorothea Terhorst-Molawi, Mitja Košnik, Kanokvalai Kulthanan, Raisa Meshkova, Simon Francis Thomsen, Marcus Maurer Cold urticaria – What we know and what we do not know. Allergy: European Journal of Allergy and Clinical Immunology. Vol.76, No.4 (2021), 1077-1094. doi:10.1111/all.14674 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77306
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Cold urticaria – What we know and what we do not know
Abstract
Cold urticaria (ColdU) is a common form of chronic inducible urticaria characterized by the development of wheals, angioedema or both in response to cold exposure. Recent research and guideline updates have advanced our understanding and management of ColdU. Today, its pathophysiology is thought to involve the cold-induced formation of autoallergens and IgE to these autoallergens, which provoke a release of proinflammatory mediators from skin mast cells. The classification of ColdU includes typical and atypical subtypes. We know that cold-induced wheals usually develop on rewarming and resolve within an hour and that anaphylaxis can occur. The diagnosis relies on the patient's history and cold stimulation testing. Additional diagnostic work-up, including a search for underlying infections, should only be done if indicated by the patient's history. The management of ColdU includes cold avoidance, the regular use of nonsedating antihistamines and the off-label use of omalizumab. However, many questions regarding ColdU remain unanswered. Here, we review what is known about ColdU, and we present important unanswered questions on the epidemiology, underlying pathomechanisms, clinical heterogeneity and treatment outcomes. Our aim is to guide future efforts that will close these knowledge gaps and advance the management of ColdU.