Publication: The reference range of CD4<sup>+</sup>and CD8<sup>+</sup>T-lymphocytes in healthy non-infected infants born to HIV-1 seropositive mothers; A preliminary study at Siriraj Hospital
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Issued Date
1998-09-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0032152413
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.29, No.3 (1998), 453-463
Suggested Citation
Sirirat Likanonsakul, Chantapong Wasi, Charin Thepthai, Ruengpung Sutthent, Suda Louisirirotchanakul, Sanay Chearskul, Niran Vanprapa, Tasanee Lebnark The reference range of CD4<sup>+</sup>and CD8<sup>+</sup>T-lymphocytes in healthy non-infected infants born to HIV-1 seropositive mothers; A preliminary study at Siriraj Hospital. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.29, No.3 (1998), 453-463. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18490
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Title
The reference range of CD4<sup>+</sup>and CD8<sup>+</sup>T-lymphocytes in healthy non-infected infants born to HIV-1 seropositive mothers; A preliminary study at Siriraj Hospital
Abstract
The results of CD4+, CD8+T- lymphocyte values as percentage, number, and ratio were studied in infants aged 1 to 29 months. The 283 subsequent blood samples from 89 infants born to HIV-1 seropositive mothers were investigated. From 208 sequential samples of 70 healthy non-infected infants, the reference values of CD4+and CD8+T-lymphocytes have been established and compared to Caucasian reference values. The results were analysed in 4 difference age groups (1-5, 6-11, 12-17 and ≥ 18 months). At age 12 months, CD4 number and percentage declined significantly while CD8 percent increased. At age 6 months CD4/CD8 ratio decreased. Of 19 infected infants CD4+percentage and number as well as CD4/ CD8 ratio declined at age 6 months and showed significant differences from uninfected infants. A significantly elevated CD8 percentage was demonstrated in infected infants at age of 12 months. In 9 infants who showed symptoms at age 6-18 months, the CD4 and CD8 values were different from the reference range and 6 of 9 patients showed lower CD4 percentage, CD4 number and reversed CD4/CD8 ratio before the symptoms appeared. In 10 infants who were asymptomatic at age 18 months, there was no evidence of immunosuppression at age 6 months or before. After age 6 months, lymphocyte subset values of some asymptomatic infected children were beyond the reference range. These preliminary findings should be very useful for monitoring children born to HIV infected mothers. The results of CD4+and CD8+T-lymphocytes in uninfected infants could be used as reference values for the Thai and other Southeast Asian pediatric populations.