Publication: Differentiation-inducing effect of piperitenone oxide, a fragrant ingredient of spearmint (Mentha spicata), but not carvone and menthol, against human colon cancer cells
Issued Date
2014-01-01
Resource Type
ISSN
17564646
Other identifier(s)
2-s2.0-84899956446
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Functional Foods. Vol.8, No.1 (2014), 62-67
Suggested Citation
Yasushi Nakamura, Yuki Hasegawa, Koji Shirota, Noboru Suetome, Takako Nakamura, Mullika Traidej Chomnawang, Krit Thirapanmethee, Piyatip Khuntayaporn, Panida Boonyaritthongchai, Chalermchai Wongs-Aree, Shigehisa Okamoto, Tomoaki Shigeta, Tomoaki Matsuo, Eun Young Park, Kenji Sato Differentiation-inducing effect of piperitenone oxide, a fragrant ingredient of spearmint (Mentha spicata), but not carvone and menthol, against human colon cancer cells. Journal of Functional Foods. Vol.8, No.1 (2014), 62-67. doi:10.1016/j.jff.2014.03.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/33159
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Differentiation-inducing effect of piperitenone oxide, a fragrant ingredient of spearmint (Mentha spicata), but not carvone and menthol, against human colon cancer cells
Abstract
The n-hexane extract from spearmint (Mentha spicata) leaves was purified via a bioassay-guided fractionation scheme, which was based on the induction of differentiation in a RCM-1 human colon cancer cell line. One of the criteria of a differentiation marker is the formation of ducts determined visually using phase contrast microscopy, the most potent fraction contained piperitenone oxide, based on EI-MS, 1H-NMR and 13C-NMR spectra. Previously, the role of piperitenone oxide was considered as an odor producing compound in spearmint cultivars, but this study indicates the potential medical benefits of this compound. The effective dose of piperitenone oxide was lower than that of any differentiation-inducers found in the bioassay. Piperitenone oxide was categorized into monoterpene such as carvone and menthol, which are also familiar ingredients in Mentha genus plants. However, carvone and menthol did not possess the differentiation-inducing effect. © 2014 Elsevier Ltd.