Publication: Hematopoietic progenitor cells in the blood and bone marrow in various hematologic disorders.
Issued Date
1998-12-01
Resource Type
ISSN
10665099
Other identifier(s)
2-s2.0-0032228205
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Stem cells (Dayton, Ohio). Vol.16 Suppl 1, (1998), 123-128
Suggested Citation
S. Issaragrisil, Y. U-pratya, M. Yimyam, K. Pakdeesuwan, A. Khuhapinant, W. Muangsup, K. Pattanapanyasat Hematopoietic progenitor cells in the blood and bone marrow in various hematologic disorders.. Stem cells (Dayton, Ohio). Vol.16 Suppl 1, (1998), 123-128. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18277
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Title
Hematopoietic progenitor cells in the blood and bone marrow in various hematologic disorders.
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Abstract
Hematopoietic progenitor cells are present in the blood and the bone marrow. Changes in the numbers of hematopoietic progenitor cells reflect alteration of pluripotent stem cells. We discuss such changes in common hematologic diseases including aplastic anemia, paroxysmal nocturnal hemoglobinuria (PNH) and thalassemia. In aplastic anemia, the numbers of burst forming units-erythroid (BFU-E) and colony-forming units-granulocyte-macrophage (CFU-GM) are much decreased; the decrease still exists after recovery from therapy. In PNH, the numbers of progenitor cells are low, even in the presence of marrow hypercellularity. In thalassemia, the numbers of progenitor cells are much increased; more pronounced in splenectomized patients.