Publication: Development of Hydronephrosis Inbred Strain Mouse, ICR/Mlac-Hydro
Issued Date
2012
Resource Type
Language
eng
ISSN
1680-5593
Rights
Mahidol University
Rights Holder(s)
Medwell Journals
Bibliographic Citation
Journal of Animal and Veterinary Advances. Vol.11, No.12 (2012), 2054-2058
Suggested Citation
Kanchana Kengkoom, Zaw, Khin Maeung, Rapee Inpunkaew, Wannee Angkasirisap, Pravate Thongsiri, Sumate Ampawong Development of Hydronephrosis Inbred Strain Mouse, ICR/Mlac-Hydro. Journal of Animal and Veterinary Advances. Vol.11, No.12 (2012), 2054-2058. doi:10.3923/javaa.2012.2054.2058 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22825
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Title
Development of Hydronephrosis Inbred Strain Mouse, ICR/Mlac-Hydro
Abstract
Hydronephrosis was accidentally observed when autopsied the out bred ICR mice in routine health monitoring program. Previously, a low incidence of mild hydronephrosis was observed mostly in male mice and found only on the right kidney. Selective inbreeding of this mutant led us to the establishment of a colony of inbred hydronephrosis mice. After inbreeding for 20 generations, a surprisingly high incidence of hydronephrosis was encountered and we finally obtained a strain of mice with a very high incidence of severe hydronephrosis affected on both sides of kidney and in both sexes as the process of inbreeding has been increased. Phenotypes determination, genetic segregation test crosses and histological study of kidneys were also performed.