Publication: Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum
Issued Date
2002-02-26
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ISSN
00319422
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2-s2.0-0037176744
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytochemistry. Vol.59, No.4 (2002), 459-463
Suggested Citation
Damrongkiet Arthan, Jisnuson Svasti, Prasat Kittakoop, Daraporn Pittayakhachonwut, Morakot Tanticharoen, Yodhathai Thebtaranonth Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum. Phytochemistry. Vol.59, No.4 (2002), 459-463. doi:10.1016/S0031-9422(01)00417-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/19991
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Title
Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum
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Abstract
The C-4 sulfated isoflavonoid, torvanol A (1), and the steroidal glycoside, torvoside H (3), together with the known glycoside, torvoside A (2), were isolated from a MeOH extract of Solanum torvum fruits. Upon enzymatic hydrolysis with β-glucosidase, torvoside A (2) and torvoside H (3) yielded the corresponding acetal derivatives 4 and 5, respectively. Torvanol A (1), torvoside H (3) and compound 5 exhibited antiviral activity (herpes simplex virus type 1) with IC50values of 9.6, 23.2 and 17.4 μg/ml, respectively. Compounds 1-5 showed no cytotoxicity (at 50 μg/ml) against BC, KB and Vero cell lines. © 2002 Elsevier Science Ltd. All rights reserved.