Publication:
Malaria in the Post-Partum Period; a Prospective Cohort Study

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dc.contributor.authorMachteld E. Boelen_US
dc.contributor.authorMarcus J. Rijkenen_US
dc.contributor.authorTjalling Leenstraen_US
dc.contributor.authorAung Pyae Phyoen_US
dc.contributor.authorMupawjay Pimanpanaraken_US
dc.contributor.authorNaw Lily Keereecharoenen_US
dc.contributor.authorStephane Prouxen_US
dc.contributor.authorNatthapon Laochanen_US
dc.contributor.authorMallika Imwongen_US
dc.contributor.authorPratap Singhasivanonen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorRose McGreadyen_US
dc.contributor.authorFrançois H. Nostenen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherAcademic Medical Centre, University of Amsterdamen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.date.accessioned2018-10-19T04:31:22Z
dc.date.available2018-10-19T04:31:22Z
dc.date.issued2013-03-13en_US
dc.description.abstractBackground: Several studies have shown a prolonged or increased susceptibility to malaria in the post-partum period. A matched cohort study was conducted to evaluate prospectively the susceptibility to malaria of post-partum women in an area where P.falciparum and P.vivax are prevalent. Methods: In an area of low seasonal malaria transmission on the Thai-Myanmar border pregnant women attending antenatal clinics were matched to a non-pregnant, non-post-partum control and followed up prospectively until 12 weeks after delivery. Results: Post-partum women (n = 744) experienced significantly less P.falciparum episodes than controls (hazard ratio (HR) 0.39 (95%CI 0.21-0.72) p = 0.003) but significantly more P.vivax (HR 1.34 (1.05-1.72) p = 0.018). The reduced risk of falciparum malaria was accounted for by reduced exposure, whereas a history of P.vivax infection during pregnancy was a strong risk factor for P.vivax in post-partum women (HR 13.98 (9.13-21.41), p<0.001). After controlling for effect modification by history of P.vivax, post-partum women were not more susceptible to P.vivax than controls (HR: 0.33 (0.21-0.51), p<0.001). Genotyping of pre-and post-partum infections (n⊕ = ⊕10) showed that each post-partum P.falciparum was a newly acquired infection. Conclusions: In this area of low seasonal malaria transmission post-partum women were less likely to develop falciparum malaria but more likely to develop vivax malaria than controls. This was explained by reduced risk of exposure and increased risk of relapse, respectively. There was no evidence for altered susceptibility to malaria in the post-partum period. The treatment of vivax malaria during and immediately after pregnancy needs to be improved. © 2013 Boel et al.en_US
dc.identifier.citationPLoS ONE. Vol.8, No.3 (2013)en_US
dc.identifier.doi10.1371/journal.pone.0057890en_US
dc.identifier.issn19326203en_US
dc.identifier.other2-s2.0-84874854224en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/31054
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84874854224&origin=inwarden_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMedicineen_US
dc.titleMalaria in the Post-Partum Period; a Prospective Cohort Studyen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84874854224&origin=inwarden_US
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