Publication: Free radicals in primary knee osteoarthritis.
Issued Date
2009-12-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-77950363981
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand = Chotmaihet thangphaet. Vol.92 Suppl 6, (2009)
Suggested Citation
Werasak Sutipornpalangkul, Noppawan Phumala Morales, Thossart Harnroongroj Free radicals in primary knee osteoarthritis.. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. Vol.92 Suppl 6, (2009). Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27824
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Title
Free radicals in primary knee osteoarthritis.
Other Contributor(s)
Abstract
Free radicals have an important role in the pathogenesis of knee osteoarthritis. Reactive oxygen species (ROS) produced by abnormal chondrocyte metabolism exceeds the physiological buffering capacity and results in oxidative stress. The excessive production of ROS can damage proteins, lipids, nucleic acids, and matrix components. They also serve as important intracellular signaling molecules that amplify the inflammatory response. An understanding of oxidative stress involved in this disease might allow the use of antioxidant therapies in the prevention and/or treatment of knee osteoarthritis.