Publication: IgE responses in human gnathostomiasis
Issued Date
1987-01-01
Resource Type
ISSN
00359203
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2-s2.0-0023517199
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Mahidol University
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SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.81, No.5 (1987), 799-801
Suggested Citation
M. H N E Soesatyo, W. Rattanasiriwilai, P. Suntharasamai, S. Sirisinha IgE responses in human gnathostomiasis. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.81, No.5 (1987), 799-801. doi:10.1016/0035-9203(87)90036-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15363
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Title
IgE responses in human gnathostomiasis
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Abstract
Specific IgE antibody levels in the serum of patients with proven gnathostomiasis and in those with intermittent cutaneous migratory swellings were determined by the enzyme-linked immunosorbent assay (ELISA) using aqueous extracts of Gnathostoma spinigerum infective larvae as antigen. There was not only an elevation of specific IgE antibody levels but also a marked increase of total IgE in the serum of these patients. The mean levels of specific IgE antibody in both groups of patients were significantly higher than that of healthy controls (P < 0·01). Only one of the 50 serum specimens tested had an ELISA reading that fell within the mean + 2 standard deviations of the control group, suggesting that the method would be useful with a high degree of reliability in confirming a clinical diagnosis of gnathostomiasis in humans. Compared with healthy controls, there was almost a 10-fold rise (P < 0·01) in the total IgE in the serum of these patients, indicating that G. spinigerum infection potentiates IgE production similarly to many other nematode parasites. © 1987.