Publication: Propofol vs isoflurane for neurosurgical anesthesia in Thai patients
Issued Date
1997-10-20
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ISSN
01252208
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2-s2.0-0030885182
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.80, No.7 (1997), 454-460
Suggested Citation
W. Ittichaikulthol, P. Srichintai, S. Pausawasdi, P. Sarnvivad Propofol vs isoflurane for neurosurgical anesthesia in Thai patients. Journal of the Medical Association of Thailand. Vol.80, No.7 (1997), 454-460. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18067
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Title
Propofol vs isoflurane for neurosurgical anesthesia in Thai patients
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Abstract
Sixty Thai patients, ASA class I-II, Glasgow coma score of 15 undergoing elective intracranial surgery were randomly assigned to 2 groups. In group I, 30 patients were induced with thiopental 3-5 mg/kg, induction with succinylcholine 1-2 mg/kg and then maintained with 60 per cent N2O in O2, isoflurane and vecuronium as a muscle relaxant. In group II, 30 patients received fentanyl 50 μg, propofol 1.0-2.5 mg/kg for induction and vecuronium 0.08 mg/kg for intubation then maintained with 60 per cent N2O in O2, continuous infusion of propofol 2-12 mg/kg/h and vecuronium as a muscle relaxant. Controlled ventilation in both groups was set to maintain PET CO2 in the range of 28-35 mmHg. 3 patients (1 in group I and 2 in group II) were excluded from the study due to surgical problems. There was no statistical difference in age, sex, ASA status, weight, duration of anesthesia. Group II had a more stable systolic BP, Diastolic BP and Pulse rate than Group I during induction and emergence from anesthesia. Glasgow coma scores in the recovery period, Group II had higher scores than Group I at 5 and 15 minutes but not at 30 minutes. Mean recovery times (eye opening) was 14.03±4.85 minutes in group I which is significantly different from 10±5.17 minutes in group II. The cost of anesthesia in group II was 1.3 times that of group I. In conclusion, although neurosurgical anesthesia for Thai patients with fentanyl-propofol technique produces more stable blood pressure during intubation and emergence, rapid recovery from anesthesia and a higher Glasgow coma score, the cost of anesthesia is more expensive. Furthermore, this technique is more difficult and needs more experience.