Publication: Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs
Issued Date
2010-03-01
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ISSN
15461718
10614036
10614036
DOI
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2-s2.0-77649188974
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Mahidol University
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SCOPUS
Bibliographic Citation
Nature Genetics. Vol.42, No.3 (2010), 268-271
Suggested Citation
Jianbing Mu, Rachel A. Myers, Hongying Jiang, Shengfa Liu, Stacy Ricklefs, Michael Waisberg, Kesinee Chotivanich, Polrat Wilairatana, Srivicha Krudsood, Nicholas J. White, Rachanee Udomsangpetch, Liwang Cui, May Ho, Fengzhen Ou, Haibo Li, Jianping Song, Guoqiao Li, Xinhua Wang, Suon Seila, Sreng Sokunthea, Duong Socheat, Daniel E. Sturdevant, Stephen F. Porcella, Rick M. Fairhurst, Thomas E. Wellems, Philip Awadalla, Xin Zhuan Su Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs. Nature Genetics. Vol.42, No.3 (2010), 268-271. doi:10.1038/ng.528 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28780
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Title
Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs
Author(s)
Jianbing Mu
Rachel A. Myers
Hongying Jiang
Shengfa Liu
Stacy Ricklefs
Michael Waisberg
Kesinee Chotivanich
Polrat Wilairatana
Srivicha Krudsood
Nicholas J. White
Rachanee Udomsangpetch
Liwang Cui
May Ho
Fengzhen Ou
Haibo Li
Jianping Song
Guoqiao Li
Xinhua Wang
Suon Seila
Sreng Sokunthea
Duong Socheat
Daniel E. Sturdevant
Stephen F. Porcella
Rick M. Fairhurst
Thomas E. Wellems
Philip Awadalla
Xin Zhuan Su
Rachel A. Myers
Hongying Jiang
Shengfa Liu
Stacy Ricklefs
Michael Waisberg
Kesinee Chotivanich
Polrat Wilairatana
Srivicha Krudsood
Nicholas J. White
Rachanee Udomsangpetch
Liwang Cui
May Ho
Fengzhen Ou
Haibo Li
Jianping Song
Guoqiao Li
Xinhua Wang
Suon Seila
Sreng Sokunthea
Duong Socheat
Daniel E. Sturdevant
Stephen F. Porcella
Rick M. Fairhurst
Thomas E. Wellems
Philip Awadalla
Xin Zhuan Su
Other Contributor(s)
National Institute of Allergy and Infectious Diseases
University of Montreal
North Carolina State University
Xiamen University
National Institutes of Health, Bethesda
Mahidol University
Pennsylvania State University
University of Calgary
Research Center for Qinghao
Guangzhou University of Traditional Chinese Medicine
National Center for Parasitology, Entomology and Malaria Control
University of Montreal
North Carolina State University
Xiamen University
National Institutes of Health, Bethesda
Mahidol University
Pennsylvania State University
University of Calgary
Research Center for Qinghao
Guangzhou University of Traditional Chinese Medicine
National Center for Parasitology, Entomology and Malaria Control
Abstract
Antimalarial drugs impose strong selective pressure on Plasmodium falciparum parasites and leave signatures of selection in the parasite genome; screening for genes under selection may suggest potential drug or immune targets. Genome-wide association studies (GWAS) of parasite traits have been hampered by the lack of high-throughput genotyping methods, inadequate knowledge of parasite population history and time-consuming adaptations of parasites to in vitro culture. Here we report the first Plasmodium GWAS, which included 189 culture-adapted P. falciparum parasites genotyped using a custom-built Affymetrix molecular inversion probe 3K malaria panel array with a coverage of 1 SNP per 7 kb. Population structure, variation in recombination rate and loci under recent positive selection were detected. Parasite half-maximum inhibitory concentrations for seven antimalarial drugs were obtained and used in GWAS to identify genes associated with drug responses. This study provides valuable tools and insight into the P. falciparum genome. © 2010 Nature America, Inc. All rights reserved.