Publication: Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications
Issued Date
2014-10-20
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ISSN
20411723
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2-s2.0-84923372413
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Mahidol University
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SCOPUS
Bibliographic Citation
Nature Communications. Vol.5, (2014)
Suggested Citation
Dong Wook Park, Amelia A. Schendel, Solomon Mikael, Sarah K. Brodnick, Thomas J. Richner, Jared P. Ness, Mohammed R. Hayat, Farid Atry, Seth T. Frye, Ramin Pashaie, Sanitta Thongpang, Zhenqiang Ma, Justin C. Williams Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications. Nature Communications. Vol.5, (2014). doi:10.1038/ncomms6258 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/33215
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Title
Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications
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Abstract
© 2014 Macmillan Publishers Limited. All rights reserved. Neural micro-electrode arrays that are transparent over a broad wavelength spectrum from ultraviolet to infrared could allow for simultaneous electrophysiology and optical imaging, as well as optogenetic modulation of the underlying brain tissue. The long-term biocompatibility and reliability of neural micro-electrodes also require their mechanical flexibility and compliance with soft tissues. Here we present a graphene-based, carbon-layered electrode array (CLEAR) device, which can be implanted on the brain surface in rodents for high-resolution neurophysiological recording. We characterize optical transparency of the device at >90% transmission over the ultraviolet to infrared spectrum and demonstrate its utility through optical interface experiments that use this broad spectrum transparency. These include optogenetic activation of focal cortical areas directly beneath electrodes, in vivo imaging of the cortical vasculature via fluorescence microscopy and 3D optical coherence tomography. This study demonstrates an array of interfacing abilities of the CLEAR device and its utility for neural applications.