Publication: De novo food allergy in pediatric liver transplantation recipients
2
Issued Date
2018-09-01
Resource Type
ISSN
22288694
0125877X
0125877X
Other identifier(s)
2-s2.0-85054439649
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.36, No.3 (2018), 166-174
Suggested Citation
Ratchaneewan Sinitkul, Wiparat Manuyakorn, Wasu Kamchaisatian, Soamarat Vilaiyuk, Suwat Benjaponpitak, Chatmanee Lertudompholwanit, Suporn Treepongkaruna De novo food allergy in pediatric liver transplantation recipients. Asian Pacific Journal of Allergy and Immunology. Vol.36, No.3 (2018), 166-174. doi:10.12932/AP-080217-0007 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/45971
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
De novo food allergy in pediatric liver transplantation recipients
Other Contributor(s)
Abstract
© 2018, Allergy and Immunology Society of Thailand. All rights reserved. Background: Food allergy (FA) prevalence is increasing in pediatric liver transplantation (LT). However, the clinical course is still limited. Objective: This retrospective cohort study aimed to identify the prevalence, risk factors, and the natural history of de novo FA in children post LT. Methods: Medical records of pediatric LT recipients from Jan 2001-Dec 2014 were reviewed. De novo FA was diagnosed by symptoms after exposure to culprit food occurring after LT, and improvement after diet elimination. FA was confirmed if reproduced symptoms after re-challenge or documented sensitization or indicated gastrointestinal eosinophilia. Results: Among 46 post LT children, 54.3% developed de novo FA at a median time of 12.2 months [Interquartile range (IQR) 6.2, 21.3 months] post LT. The confirmed FA was 39.1%. Gastrointestinal symptom was the most common manifestation followed by skin, anaphylaxis, and others. Culprit foods were cow’s milk, shellfish, egg, wheat, soybean, peanut, coconut, fish and monosodium glutamate. The risk factors of FA were transplantation during age below 2 years [hazard ratio (HR), 2.62; 95% confidence interval (CI), 1.04-6.59; p = 0.03), atopic history in family (HR, 5.67; 95% CI, 1.33-24.12; p = 0.01), and Epstein-Barr (EBV) viremia (HR, 2.39; 95% CI, 1.02-5.63; p = 0.04). Conclusions: de novo FA in pediatric LT is not uncommon. Age at LT younger than 2 years, family history of atopy, and EBV viremia are associated with developing FA. Development of tolerance after elimination culprit diets for 3 years is similar to general population.