Publication: Spray-dried rice starch: Comparative evaluation of direct compression fillers
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Issued Date
1996-01-01
Resource Type
ISSN
03639045
Other identifier(s)
2-s2.0-0030017245
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Mahidol University
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SCOPUS
Bibliographic Citation
Drug Development and Industrial Pharmacy. Vol.22, No.7 (1996), 587-594
Suggested Citation
Ampol Mitrevej, Nuttanan Sinchaipanid, Damrongsak Faroongsarng Spray-dried rice starch: Comparative evaluation of direct compression fillers. Drug Development and Industrial Pharmacy. Vol.22, No.7 (1996), 587-594. doi:10.3109/03639049609063212 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17585
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Title
Spray-dried rice starch: Comparative evaluation of direct compression fillers
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Abstract
Spray-dried rice starch (SDRS), microcrystalline cellulose (MCC), lactose (L), pregelatinized starch (PS), and dibasic calcium phosphate (DCP) were studied for their flow behaviors and tableting properties. Both flow rate and percent compressibility values indicated that SDRS exhibited excellent flowability. The increase in magnesium stearate content reduced the hardness of MCC and SDRS tablets; however, general tablet properties were still acceptable while the PS tablets were unsatisfactory at high lubricant concentrations. The hardness of L or DCP tablets was not affected by the lubricant. The disintegration of L tablets was prolonged with the increased lubricant concentration while that of PS tablets seemed to be decreased due to softened tablets. The disintegration times of MCC and SDRS tablets seemed to be independent of the lubricant added. With respect to the dissolution, SDRS-based tablets offered fast and complete release of the drug regardless of its solubility. SDRS, L, and DCP exhibited comparable carrying capacity for ascorbic acid. The best dilution potential was obtained with MCC while the worst was obtained with PS.