Publication: Amniotic membrane transplantation for symptomatic bullous keratopathy
Issued Date
1999-01-01
Resource Type
ISSN
00039950
Other identifier(s)
2-s2.0-0033391702
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Mahidol University
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SCOPUS
Bibliographic Citation
Archives of Ophthalmology. Vol.117, No.10 (1999), 1291-1297
Suggested Citation
Renato T.F. Pires, Scheffer C.G. Tseng, Pinnita Prabhasawat, Vilavun Puangsricharern, Steven L. Maskin, Jae Chan Kim, Donald T.H. Tan Amniotic membrane transplantation for symptomatic bullous keratopathy. Archives of Ophthalmology. Vol.117, No.10 (1999), 1291-1297. doi:10.1001/archopht.117.10.1291 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/25770
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Title
Amniotic membrane transplantation for symptomatic bullous keratopathy
Abstract
Objective: To determine whether amniotic membrane transplantation can be used to treat symptomatic bullous keratopathy displaying poor visual potential. Methods: Amniotic membrane transplantation was performed at 5 centers on 50 consecutive eyes (50 patients) with symptomatic bullous keratopathy and poor visual potential. The underlying causes of bullous keratopathy included aphakia (9 eyes), pseudophakia (19 eyes), failed grafts (9 eyes), and others (13 eyes). Results: During the follow-up period of 33.8 weeks (3-96 weeks) after amniotic membrane transplantation, 43 (90%) of 48 eyes with intolerable pain preoperatively became pain free postoperatively. Among the 5 eyes with residual pain, 3 received repeated amniotic membrane transplantation, 1 required a conjunctival flap for pain relief, and 1 had reduced pain. Epithelial defects in 45 (90%) of 50 eyes created and covered by amniotic membrane healed rapidly within 3 weeks. Only 4 eyes (8%) showed recurrent surface breakdown. Epithelial edema or bullae recurred in a smaller area in 5 eyes (10%) and pseudopterygium developed in 1 eye. Conclusion: Amniotic membrane transplantation can be considered as an alternative to conjunctival flaps in alleviating pain, promoting epithelial healing, and preserving cosmetic appearance in patients with symptomatic bullous keratopathy and poor visual potential.