Publication: Recent advances in understanding dengue
Issued Date
2016-01-01
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ISSN
1759796X
20461402
20461402
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2-s2.0-84970959895
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Mahidol University
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SCOPUS
Bibliographic Citation
F1000Research. Vol.5, (2016)
Suggested Citation
Sophie Yacoub, Juthathip Mongkolsapaya, Gavin Screaton Recent advances in understanding dengue. F1000Research. Vol.5, (2016). doi:10.12688/f1000research.6233.1 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/43250
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Title
Recent advances in understanding dengue
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Abstract
© 2016 Yacoub S et al. Dengue is an emerging threat to billions of people worldwide. In the last 20 years, the incidence has increased four-fold and this trend appears to be continuing. Caused by one of four viral serotypes, dengue can present as a wide range of clinical phenotypes with the severe end of the spectrum being defined by a syndrome of capillary leak, coagulopathy, and organ impairment. The pathogenesis of severe disease is thought to be in part immune mediated, but the exact mechanisms remain to be defined. The current treatment of dengue relies on supportive measures with no licensed therapeutics available to date. There have been recent advances in our understanding of a number of areas of dengue research, of which the following will be discussed in this review: the drivers behind the global dengue pandemic, viral structure and epitope binding, risk factors for severe disease and its pathogenesis, as well as the findings of recent clinical trials including therapeutics and vaccines. We conclude with current and future dengue control measures and key areas for future research.