Publication: Effects of temperature, humidity, and aging on the disintegration and dissolution of acetaminophen tablets
15
Issued Date
1988-01-01
Resource Type
ISSN
03639045
Other identifier(s)
2-s2.0-0023676084
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Drug Development and Industrial Pharmacy. Vol.14, No.13 (1988), 1877-1881
Suggested Citation
Narong Sarisuta, Eugene L. Parrott Effects of temperature, humidity, and aging on the disintegration and dissolution of acetaminophen tablets. Drug Development and Industrial Pharmacy. Vol.14, No.13 (1988), 1877-1881. doi:10.3109/03639048809151993 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15526
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Title
Effects of temperature, humidity, and aging on the disintegration and dissolution of acetaminophen tablets
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Abstract
The effect of storage for 8 weeks at 40°C in moderate and high humidity on acetaminophen tablets prepared by the wet granulation method using povidone or pregelatinized starch as a binder was studies. Storage at 52% relative humidity produced an increase in hardness of acetaminophen tablets and storage at 94% relative humidity caused a decrease in hardness. In all cases tablets granulated with pregelatinized starch were less susceptible to change caused by humidity than tablets granulated with povidone. The disintegration of tablets containing starch or povidone was slowed as the humidity was increased. Tablets stored at 40 =C and 94 V. relative humidity showed a substantial slowing of dissolution, but there was little change of dissolution of tablets when aged at 40 -C / 52% relative humidity. In comparing starch and povidone as binders, acetaminophen tablets prepared with pregelatinized starch were less effected by high humidity than tablets prepared with povidone. © 1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.