Publication: Laboratory assessment of thrombolytic therapy in acute myocardial infarction.
Issued Date
1993-12-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0027902627
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
The Southeast Asian journal of tropical medicine and public health. Vol.24 Suppl 1, (1993), 144-148
Suggested Citation
P. Talalak, S. Chaithiraphan, N. Opartkiattikul, W. Leowattana, W. Sangtawesin, D. Tresukosol Laboratory assessment of thrombolytic therapy in acute myocardial infarction.. The Southeast Asian journal of tropical medicine and public health. Vol.24 Suppl 1, (1993), 144-148. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/22651
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Laboratory assessment of thrombolytic therapy in acute myocardial infarction.
Other Contributor(s)
Abstract
Hemostatic profiles and cardiac enzymes were studied in 55 acute myocardial infarct (AMI) patients to assess SK and rt-PA therapy. Hypofibrinogenemia occurred 85% in SK group and 55% in rt-PA group with high FDP and D-Dimer, indicating systemic fibrinogenolysis and local crosslinked fibrin clot lysis. The incidence of bleeding in SK and rt-PA groups combined with anticoagulants were the same but lower in rt-PA with antiplatelet. The mean FDP was significantly higher in the bleeding group (p < 0.01). Cardiac enzymes: CK, CK-MB peak values indicated reperfusion were 26.6%, 60% and 90% in conventional, SK and rt-PA therapy, respectively. Early and late occlusion did not occur either in SK or rt-PA followed by anticoagulants. Late occlusion was found in patients treated with rt-PA and antiplatelet. Mortality rate was 20% in conventional therapy.