Publication:
Cotrimoxazole prophylaxis decreases tuberculosis risk among Asian patients with HIV

Issued Date

2019-03-01

Resource Type

Article

ISSN

17582652

DOI

10.1002/jia2.25264

Other identifier(s)

2-s2.0-85063688788

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of the International AIDS Society. Vol.22, No.3 (2019)

Suggested Citation

Stephane Wen Wei Ku, Awachana Jiamsakul, Kedar Joshi, Mark Kristoffer Ungos Pasayan, Alvina Widhani, Romanee Chaiwarith, Sasisopin Kiertiburanakul, Anchalee Avihingsanon, Penh Sun Ly, Nagalingeswaran Kumarasamy, Cuong D. Do, Tuti P. Merati, Kinh Van Nguyen, Adeeba Kamarulzaman, Fujie Zhang, Man Po Lee, Jun Yong Choi, Junko Tanuma, Suwimon Khusuwan, Benedict Lim Heng Sim, Oon Tek Ng, Winai Ratanasuwan, Jeremy Ross, Wing Wai Wong, P. S. Ly, V. Khol, F. J. Zhang, H. X. Zhao, N. Han, M. P. Lee, P. C.K. Li, W. Lam, Y. T. Chan, N. Kumarasamy, S. Saghayam, C. Ezhilarasi, S. Pujari, K. Joshi, S. Gaikwad, A. Chitalikar, S. Sangle, V. Mave, I. Marbaniang, D. N. Wirawan, F. Yuliana, E. Yunihastuti, D. Imran, J. Tanuma, S. Oka, T. Nishijima, J. Y. Choi, S. Na, J. M. Kim, B. L.H. Sim, Y. M. Gani, N. B. Rudi, A. Kamarulzaman, S. F. Syed Omar, S. Ponnampalavanar, I. Azwa, R. Ditangco, M. L. Mationg, W. W. Wong, S. W.W. Ku, P. C. Wu, O. T. Ng, P. L. Lim, L. S. Lee, Z. Ferdous, A. vihingsanon, S. Gatechompol, P. Phanuphak, C. Phadungphon, S. Kiertiburanakul, A. Phuphuakrat, L. Chumla, N. Sanmeema, T. Sirisanthana, W. Kotarathititum, J. Praparattanapan, P. Kantipong, P. Kambua, W. Ratanasuwan, R. Sriondee, K. V. Nguyen, H. V. Bui, D. T.H. Nguyen, D. T. Nguyen, C. D. Do, A. V. Ngo, L. T. Nguyen, A. H. Sohn, J. L. Ross, B. Petersen, D. A. Cooper, M. G. Law Cotrimoxazole prophylaxis decreases tuberculosis risk among Asian patients with HIV. Journal of the International AIDS Society. Vol.22, No.3 (2019). doi:10.1002/jia2.25264 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/51849

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Cotrimoxazole prophylaxis decreases tuberculosis risk among Asian patients with HIV

Author(s)

Stephane Wen Wei Ku
 Awachana Jiamsakul
 Kedar Joshi
 Mark Kristoffer Ungos Pasayan
 Alvina Widhani
 Romanee Chaiwarith
 Sasisopin Kiertiburanakul
 Anchalee Avihingsanon
 Penh Sun Ly
 Nagalingeswaran Kumarasamy
 Cuong D. Do
 Tuti P. Merati
 Kinh Van Nguyen
 Adeeba Kamarulzaman
 Fujie Zhang
 Man Po Lee
 Jun Yong Choi
 Junko Tanuma
 Suwimon Khusuwan
 Benedict Lim Heng Sim
 Oon Tek Ng
 Winai Ratanasuwan
 Jeremy Ross
 Wing Wai Wong
 P. S. Ly
 V. Khol
 F. J. Zhang
 H. X. Zhao
 N. Han
 M. P. Lee
 P. C.K. Li
 W. Lam
 Y. T. Chan
 N. Kumarasamy
 S. Saghayam
 C. Ezhilarasi
 S. Pujari
 K. Joshi
 S. Gaikwad
 A. Chitalikar
 S. Sangle
 V. Mave
 I. Marbaniang
 D. N. Wirawan
 F. Yuliana
 E. Yunihastuti
 D. Imran
 J. Tanuma
 S. Oka
 T. Nishijima
 J. Y. Choi
 S. Na
 J. M. Kim
 B. L.H. Sim
 Y. M. Gani
 N. B. Rudi
 A. Kamarulzaman
 S. F. Syed Omar
 S. Ponnampalavanar
 I. Azwa
 R. Ditangco
 M. L. Mationg
 W. W. Wong
 S. W.W. Ku
 P. C. Wu
 O. T. Ng
 P. L. Lim
 L. S. Lee
 Z. Ferdous
 A. vihingsanon
 S. Gatechompol
 P. Phanuphak
 C. Phadungphon
 S. Kiertiburanakul
 A. Phuphuakrat
 L. Chumla
 N. Sanmeema
 T. Sirisanthana
 W. Kotarathititum
 J. Praparattanapan
 P. Kantipong
 P. Kambua
 W. Ratanasuwan
 R. Sriondee
 K. V. Nguyen
 H. V. Bui
 D. T.H. Nguyen
 D. T. Nguyen
 C. D. Do
 A. V. Ngo
 L. T. Nguyen
 A. H. Sohn
 J. L. Ross
 B. Petersen
 D. A. Cooper
 M. G. Law

Other Contributor(s)

Hospital Sungai Buloh
 Beijing Ditan Hospital Capital Medical University
 VHS Medical Centre India
 Gokila
 Bach Mai Hospital
 Universitas Udayana
 University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
 Chulalongkorn University
 Taipei City Hospital Taiwan
 Kirby Institute
 National Center for Global Health and Medicine
 Yonsei University College of Medicine
 Faculty of Medicine, Ramathibodi Hospital, Mahidol University
 Queen Elizabeth Hospital Hong Kong
 University of Malaya Medical Centre
 Veterans General Hospital-Taipei
 Faculty of Medicine, Siriraj Hospital, Mahidol University
 Tan Tock Seng Hospital
 Chiang Mai University
 Dermatology & STDs and University of Health Sciences
 National Hospital for Tropical Diseases
 Foundation for AIDS Research
 Institute of Infectious Diseases
 Chiangrai Prachanukroh Hospital

Abstract

© 2019 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society. Introduction: Cotrimoxazole (CTX) is recommended as prophylaxis against Pneumocystis jiroveci pneumonia, malaria and other serious bacterial infections in HIV-infected patients. Despite its in vitro activity against Mycobacterium tuberculosis, the effects of CTX preventive therapy on tuberculosis (TB) remain unclear. Methods: Adults living with HIV enrolled in a regional observational cohort in Asia who had initiated combination antiretroviral therapy (cART) were included in the analysis. Factors associated with new TB diagnoses after cohort entry and survival after cART initiation were analysed using Cox regression, stratified by site. Results: A total of 7355 patients from 12 countries enrolled into the cohort between 2003 and 2016 were included in the study. There were 368 reported cases of TB after cohort entry with an incidence rate of 0.99 per 100 person-years (/100 pys). Multivariate analyses adjusted for viral load (VL), CD4 count, body mass index (BMI) and cART duration showed that CTX reduced the hazard for new TB infection by 28% (HR 0.72, 95% CI l 0.56, 0.93). Mortality after cART initiation was 0.85/100 pys, with a median follow-up time of 4.63 years. Predictors of survival included age, female sex, hepatitis C co-infection, TB diagnosis, HIV VL, CD4 count and BMI. Conclusions: CTX was associated with a reduction in the hazard for new TB infection but did not impact survival in our Asian cohort. The potential preventive effect of CTX against TB during periods of severe immunosuppression should be further explored.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/51849

Collections

Scopus 2019