Publication: Tumour necrosis factor-alpha gene polymorphisms and susceptibility to oral lichen planus
Issued Date
2011-03-01
Resource Type
ISSN
16010825
1354523X
1354523X
Other identifier(s)
2-s2.0-79951562026
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Mahidol University
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SCOPUS
Bibliographic Citation
Oral Diseases. Vol.17, No.2 (2011), 206-209
Suggested Citation
I. Kimkong, N. Hirankarn, J. Nakkuntod, N. Kitkumthorn Tumour necrosis factor-alpha gene polymorphisms and susceptibility to oral lichen planus. Oral Diseases. Vol.17, No.2 (2011), 206-209. doi:10.1111/j.1601-0825.2010.01722.x Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/11836
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Title
Tumour necrosis factor-alpha gene polymorphisms and susceptibility to oral lichen planus
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Abstract
Objective: This study is aimed to investigate the association between OLP susceptibility and clinical type in the Thai population and three polymorphisms within the promoter region of the TNF-α at positions -863, -308 and -238 which have putative functional significances. Materials and Methods: Genomic DNA from 75 Thai patients with OLP and 154 healthy controls were genotyped for TNF-α polymorphisms - -863(rs1800630), -308(rs1800629), and -238(rs361525) - using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: We found a higher proportion of TNF-alpha-308 AA genotype (high producer genotype) among OLP patients (5/75; 6.67%) when compared to healthy controls (1/154; 0.65%; OR=10.93; 95% CI=1.21-251.9). For other polymorphisms (-863 and -238), we did not find any significant association with OLP development; this was also the case with haplotype analysis (-863/-308/-238). Conclusion: TNF-α-308AA may play a relevant role in the susceptibility and severity of OLP in the Thai population. However, further investigation of this study is needed. © 2010 John Wiley & Sons A/S.