Publication: Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes
2
Issued Date
2009-06-01
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ISSN
15416100
00223166
00223166
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2-s2.0-66749084406
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Nutrition. Vol.139, No.6 (2009), 1185-1191
Suggested Citation
Akkarach Bumrungpert, Ruchaneekorn W. Kalpravidh, Chureeporn Chitchumroonchokchai, Chia Chi Chuang, Tiffany West, Arion Kennedy, Michael McIntosh Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes. Journal of Nutrition. Vol.139, No.6 (2009), 1185-1191. doi:10.3945/jn.109.106617 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28069
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Title
Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes
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Abstract
The xanthones, α- and γ-mangostin (MG), are major bioactive compounds found in mangosteen and are reported to have antiinflammatory properties in several murine models. Given the association between obesity, chronic low-grade inflammation, and insulin resistance, we examined the effects of α- and γ-MG on markers of inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes treated with lipopolysaccharide (LPS). α- and γ-MG decreased the induction by LPS of inflammatory genes, including tumor necrosis factor-α, interleukin (IL)-1β, IL-6, IL-8, monocyte chemoattractant protein-1, and Toll-like receptor-2. Moreover, α- and γ-MG attenuated LPS activation of the mitogen-activated protein kinases (MAPK) c-jun NH2-terminal kinase, extracellular signal-related kinase, and p38. α- and γ-MG also attenuated LPS activation of c-Jun and activator protein (AP)-1 activity. γ-MG was more effective than α-MG on an equimolar basis. Furthermore, γ-MG but not α-MG attenuated LPS-mediated IκB-α degradation and nuclear factor-κB (NFκB) activity. In addition, γ-MG prevented the suppression by LPS of insulin-stimulated glucose uptake and PPAR-γ and adiponectin gene expression. Taken together, these data demonstrate that MG attenuates LPS-mediated inflammation and insulin resistance in human adipocytes, possibly by inhibiting the activation of MAPK, NF-κB, and AP-1. © 2009 American Society for Nutrition.