Publication: Red cell acetylcholinesterase activity in Plasmodium falciparum malaria
Issued Date
1982-12-01
Resource Type
ISSN
00383619
Other identifier(s)
2-s2.0-0020452667
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.13, No.2 (1982), 196-201
Suggested Citation
S. Areekul, Y. Chantachum, C. Cheeramakara, K. Churdchu, P. Attanath Red cell acetylcholinesterase activity in Plasmodium falciparum malaria. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.13, No.2 (1982), 196-201. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30354
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Title
Red cell acetylcholinesterase activity in Plasmodium falciparum malaria
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Abstract
Red cell ACHE activity was determined in 19 patients with P. falciparum malaria, 13 patients during convalescence and 6 normal subjects. There was no significant difference between the mean values of ACHE in red cells of these 3 groups. After separation of these blood samples into 2 portions by centrifugation in 5% Ficoll solution, the parasitized red cells in the lower portion which are mostly ring forms contained the same amount of ACHE activity as those of the normal subjects and the non-parasitized red cells. However, the parasitized red cells in the upper portion which contained predominantly mature asexual forms revealed a significantly higher ACHE activity than those of the normal red cells. There was also a reverse relationship between red cell ACHE activity and the parasitaemia from this portion of the blood sample. These findings indicated that although malarial parasite invaded and caused the red cell membrane damage, it did not inactivate ACHE. It may be concluded that ACHE was not responsible for the anaemia and excessive erythrocyte destruction in patients with P. falciparum malaria.