Gonadal Dysgenesis (Turner's Syndrome)

Abstract

A report of 15 cases of gonadal dysgenesis (Turner's syndrome) is presented. Thirteen cases belonged to the short‐stature group and two in the normal‐stature group. All had primary amenorrhoea, elevated gonadotrophin, infantile genital organs and no secondary sex characteristics. The gonads were visualised in eight. In the short‐stature group typical gonadal dysgenesis was found in four and small ovaries with undeveloped follicles were found in two. Both patients in the normal‐stature group had gonadal dysgenesis proven by peritoneoscopy and exploratory laparotomy. For the short‐stature group 83% were chromatin negative and six were shown to have 45 XO karyotype. Both normal stature patients were chromatin positive and one had a 44 XX karyotype. A webbed neck was present in five, anomalies of the kidneys in two and colour blindness in one of the short‐stature group. No somatic anomaly was detected in the normal‐stature group. Oestrogen deficiency was present in all patients but thyroid and adrenal function were normal. © 1970 Japanese Society of Obstetrics and Gynaecology