Publication: Neurocysticercosis : utilizing the cystic fluid antigen from taenia solium metacestodes for diagnosis by IgG-Elisa
Issued Date
2000-12-01
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ISSN
01251562
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2-s2.0-0041687862
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.31, No.1 SUPPL. (2000), 21-25
Suggested Citation
Paron Dekumyoy, Malinee T. Anantaphruti, Supaporn Nuamtanong, Dorn Watthanakulpanich, Jitra Waikagul, Martin Danis Neurocysticercosis : utilizing the cystic fluid antigen from taenia solium metacestodes for diagnosis by IgG-Elisa. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.31, No.1 SUPPL. (2000), 21-25. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26076
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Title
Neurocysticercosis : utilizing the cystic fluid antigen from taenia solium metacestodes for diagnosis by IgG-Elisa
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Abstract
Cystic fluid, which has antigenic properties of whole Taenia solium cysticerci, was used to discriminate neurocysticercosis cases and other parasitic infections, especially helminthiases. Twenty-one neurocysticercosis and several kinds of 22 different parasitic infections, including HIV cases (n=234) evaluated a 90.48% sensitivity and 86.32% specificity of indirect ELISA as follows; a low antigen concentration of 5 μg/ml, serum dilution of 1:400, conjugate dilution of 1:2.000 and a cut-off value of 0.349. Eight different helminthic infections (n = 25); echinococcosis (8/10), gnathostomiasis (6/8), strongyloidiasis (5/14), hookworm infection (1/18), angiostrongyliasis (2/25), opisthorchiasis (1/18), onchocercosis (1/3) and toxocariasis (1/6) were cross-reactive with this antigen. No serum antibody from other brain infections in the study gave a reaction with the antigen. In this study, the cystic fluid antigen gave high sensitivity of the test. However, the antigen contains various antigenic molecules able to bind with antibodies from several of the above helminthic sera, especially echinococcosis and gnathostomiasis. In Thailand, gnathostomiasis is one of the more famous tropical diseases but echinococcosis is quite rare. Cystic fluid antigen should be further investigated for its specific finding in diagnosis.