Publication: Development of SEDDS/SMEDDS of sweet basil oil and fingerroot oil for using in drinking water for chickens
Issued Date
2014-01-01
Resource Type
ISSN
01256491
Other identifier(s)
2-s2.0-84912018263
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Mahidol University
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SCOPUS
Bibliographic Citation
Thai Journal of Veterinary Medicine. Vol.44, No.3 (2014), 297-305
Suggested Citation
Prapaporn Boonme, Varaporn Buraphacheep Junyaprasert Development of SEDDS/SMEDDS of sweet basil oil and fingerroot oil for using in drinking water for chickens. Thai Journal of Veterinary Medicine. Vol.44, No.3 (2014), 297-305. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34962
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Thesis
Title
Development of SEDDS/SMEDDS of sweet basil oil and fingerroot oil for using in drinking water for chickens
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Abstract
This study aimed to develop self-emulsifying drug delivery systems or self-microemulsifying drug delivery systems (SEDDS/SMEDDS) to thoroughly mix sweet basil oil and fingerroot oil in drinking water for chickens in order to utilize for cocidiosis prevention and treatment. Effects of surfactant and cosolvent type on the formulations were investigated. The selected formulations were then investigated for physical properties. In addition, the chemical stability of the formulations was studied by Gas Chromatography-Mass Spectrophotometry (GC-MS) after kept in three different conditions, i.e., 5±3 °C (in a refrigerator), 30±2 °C/75±5%RH, and 45±2 °C/75±5%RH, for four months. It was found that both sweet basil oil and fingerroot oil could be mixed with Tween80 to obtain clear yellowish liquids which further possibly formed into emulsions when diluted with water at appropriate concentrations. Both volatile oils provided small microemulsion regions when mixed with Tween80 and water. CremophorRH40 used as a surfactant had superior in mixing both volatile oils in SEDDS/SMEDDS formulations than Tween80 while polyethylene glycol 400 (PEG400) and propylene glycol (PG) showed similar efficacy as cosolvents. Finally, the SEDDS/SMEDDS formulations composed of CremophorRH40, PEG400 or PG, and sweet basil oil or fingerroot oil were successfully developed for homogeneously mixing in drinking water for chickens. All selected samples were clear liquid having spherical particles in nanometer-range (12.3-52.4 nm). The results also indicated that all samples were chemically stable when stored in well-closed containers at low temperature.
