Publication: Determination of whole transcription profiles and specific pathways in invasive ductal breast carcinoma
Accepted Date
2013-03-26
Issued Date
2013-05-15
Copyright Date
2013
Resource Type
Language
eng
ISSN
1936-2625 (electronic)
Rights
Mahidol University
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International journal of clinical and experimental pathology/ Free PMC Article
Bibliographic Citation
Arnutti P, Kotepui M, Asanprakit W, Punyarit P, Chavalitshewinkoon-Petmitr P, Harnroongroj T. et al. Determination of whole transcription profiles and specific pathways in invasive ductal breast carcinoma. Int J Clin Exp Pathol. 2013 May 15;6(6):1112-20.
Suggested Citation
Pasra Arnutti, ภัสรา อาณัติ, Manas Kotepui, มนัส โคตรพุ้ย, Wichitra Asanprakit, Phaibul Punyarit, Porntip Chavalitshewinkoon-Petmitr, พรทิพย์ ชวลิตรชีวินกุล เพ็ชรมิตร, Talabporn Harnroongroj, ตรับพร หาญรุ่งโรจน์, Songsak Petmitr, ทรงศักดิ์ เพ็ชรมิตร Determination of whole transcription profiles and specific pathways in invasive ductal breast carcinoma. Arnutti P, Kotepui M, Asanprakit W, Punyarit P, Chavalitshewinkoon-Petmitr P, Harnroongroj T. et al. Determination of whole transcription profiles and specific pathways in invasive ductal breast carcinoma. Int J Clin Exp Pathol. 2013 May 15;6(6):1112-20.. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/821
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Title
Determination of whole transcription profiles and specific pathways in invasive ductal breast carcinoma
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Abstract
Breast cancer is the most common cancer affecting women worldwide including
Thailand. Whole transcription profiles of invasive ductal breast carcinoma (IDC)
obtained by oligonucleotide microarray should lead to a better understanding of
the molecular basis of IDCs, allow for examination of specific markers for
diagnosis, and provide novel targets for therapy. This study aimed to detect the
whole transcript expression of approximately 35,000 target genes in Thai breast
cancer patients, using Affymetrix GeneChip(®) Exon 1.0 Sense Target Arrays.
Analysis revealed that the differential expression profiles of 928 genes (423
up-regulated and 505 down-regulated genes) were 2-fold or greater (unpaired
t-test, p < 0.05) in invasive ductal breast cancer, compared with normal tissues.
The Gene Ontology (GO) databases support important associations in 17 gene sets
with p-value < 1E-10 and ≥ 4-fold changes, involving the tumorigenic pathways of
cell cycles, extracellular regions, as well as cellular component organization.
Likewise, the TGFBR and IL-6 pathways contain gene expression with statistically
significant changes in IDC.