Publication: Fabrication and evaluation of Eudragit<sup>®</sup> polymeric films for transdermal delivery of piroxicam
Issued Date
2018-09-14
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ISSN
10979867
10837450
10837450
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2-s2.0-85018389236
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Mahidol University
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SCOPUS
Bibliographic Citation
Pharmaceutical Development and Technology. Vol.23, No.8 (2018), 771-779
Suggested Citation
Doungdaw Chantasart, Preeda Tocanitchart, Amaraporn Wongrakpanich, Veerawat Teeranachaideekul, Varaporn Buraphacheep Junyaprasert Fabrication and evaluation of Eudragit<sup>®</sup> polymeric films for transdermal delivery of piroxicam. Pharmaceutical Development and Technology. Vol.23, No.8 (2018), 771-779. doi:10.1080/10837450.2017.1319864 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/47298
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Fabrication and evaluation of Eudragit<sup>®</sup> polymeric films for transdermal delivery of piroxicam
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Abstract
© 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group. The aims of this work were to develop and characterize the prolonged release piroxicam transdermal patch as a prototype to substitute oral formulations, to reduce side effects and improve patient compliance. The patches were composed of film formers (Eudragit®) as a matrix backbone, with PVC as a backing membrane and PEG200 used as a plasticizer. Results from X-ray diffraction patterns and Fourier transform-infrared spectroscopy indicated that loading piroxicam into films changed the drug crystallinity from needle to an amorphous or dissolved form. Piroxicam films were prepared using Eudragit® RL100 and Eudragit® RS100 as film formers at various ratios from 1:0 to 1:3. Films prepared solely by Eudragit® RL100 showed the toughest and softest film, while other formulations containing Eudragit® RS100 were hard and brittle. Drug release kinetic data from the films fitted with the Higuchi model, and the piroxicam release mechanism was diffusion controlled. Among all formulation tested, Eudragit® RL100 films showed the highest drug release rate and the highest drug permeation flux across human epidermal membrane. Increasing drug loading led to an increase in drug release rate. Eudragit® can be used as a film former for the fabrication of piroxicam films.