Publication: The effect of 0.5% levo-bupivacaine scalp block during craniotomy: A double-blind randomized placebo controlled trial
Issued Date
2018-09-01
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01252208
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2-s2.0-85064208505
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.101, No.9 (2018), S59-S65
Suggested Citation
Manee Raksakietisak, Pajongjit Suwansukroad, Taschan Uengkajornkul, Pranee Rushatamukayanunt The effect of 0.5% levo-bupivacaine scalp block during craniotomy: A double-blind randomized placebo controlled trial. Journal of the Medical Association of Thailand. Vol.101, No.9 (2018), S59-S65. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46349
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Title
The effect of 0.5% levo-bupivacaine scalp block during craniotomy: A double-blind randomized placebo controlled trial
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Abstract
© 2018, Medical Association of Thailand. All rights reserved. Objective: The objectives of the present study are to evaluate the scalp block efficacy in term of perioperative use of analgesic (fentanyl), awakening time, hemodynamic stability and postcraniotomy pain control. Materials and Methods: One hundred and thirty (18 to 75 years old) patients were enrolled and allocated into 2 groups by computer-generated randomization. Group N received scalp block with 0.9% Normal saline solution [NSS] and group L received scalp block with 0.5% levo-bupivacaine 10 to 15 mL. Both groups also received pre-incisional local anesthetic infiltration from neurosurgeons due to their routine practice (a mixture of 0.5% bupivacaine 10 mL and 1% lidocaine with epinephrine 1: 200,000 10 mL) and intravenous fentanyl for intra-operative pain control. The assessed outcomes were intraoperative total fentanyl consumption, hemodynamic stability, awakening time, pain scores, postoperative morphine consumption, nausea and vomiting. Results: One hundred and twenty-eight patients were analyzed with 64 patients in each group. There were no differences in patient demographics, fentanyl consumption, and awakening time. In group L, the median postoperative pain score was significantly lower at 4th hour (group L 5 (3, 6) vs. group N 6 (4, 8),p = 0.029). However, group L had higher incidence of hypotension (group L 84.4% vs. group N 68.7%, p = 0.037). Conclusion: The scalp block with 0.5% levo-bupivacaine, added up to intravenous fentanyl and local infiltration, provided slightly better postoperative pain control for craniotomy.