Publication: Novel activities of 1-Adamantylthiopyridines as antibacterials, antimalarials and anticancers
Issued Date
2009-12-01
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ISSN
16112156
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2-s2.0-70349916584
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Mahidol University
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SCOPUS
Bibliographic Citation
EXCLI Journal. Vol.8, (2009), 121-129
Suggested Citation
Supaluk Prachayasittikul, Lertyot Treeratanapiboon, Somsak Ruchirawat, Virapong Prachayasittikul Novel activities of 1-Adamantylthiopyridines as antibacterials, antimalarials and anticancers. EXCLI Journal. Vol.8, (2009), 121-129. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26958
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Title
Novel activities of 1-Adamantylthiopyridines as antibacterials, antimalarials and anticancers
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Abstract
To discover new bioactive lead compounds for medicinal purposes, herein, 2(1-adamantylthio)pyridine and derivatives (1-10) were prepared and tested for antibacterial (agar dilution method against 27 strains of microorganisms), antimalarial (against Plasmodium falciparum) and anticancer (MOLT-3, HepG2, HuCCA-1 and A549) activities. Results showed that all the tested derivatives selectively exerted antigrowth activity against Streptococci at 15-30 μg/mL. 3-Substituted (R) thiopyridines; 3 (R = NAc2), 5 (R = OH) and 6 (R = Br) exhibited antibacterials, antimalarials and anticancers. Significantly, 6-(1-adamantylthio) nicotinonitrile (10) is a promising antibacterial which selectively displays antigrowth activity against Vibrio cholerae, Vibrio parahaemolyticus, Edwardsiella tarda and β-hemolytic Streptococcus group A with minimum inhibitory concentration of 30 μg/mL. The findings reveal that these 1-adamantylthiopyridines represent a novel class of antibacterial, antimalarial and anticancer agents with potential medicinal values.