Publication: Reducing effects of rodent malaria on hepatic carcinogenesis induced by dietary aflatoxin B<inf>1</inf>
Issued Date
1988-01-01
Resource Type
ISSN
10970215
00207136
00207136
Other identifier(s)
2-s2.0-0023833239
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Cancer. Vol.41, No.1 (1988), 69-73
Suggested Citation
Subhkij Angsubhakorn, Natth Bhamarapravati, Somphong Sahaphong, Permsin Sathiropas Reducing effects of rodent malaria on hepatic carcinogenesis induced by dietary aflatoxin B<inf>1</inf>. International Journal of Cancer. Vol.41, No.1 (1988), 69-73. doi:10.1002/ijc.2910410114 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15530
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Title
Reducing effects of rodent malaria on hepatic carcinogenesis induced by dietary aflatoxin B<inf>1</inf>
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Abstract
The present study was undertaken to evaluate the effects of Plasmodium berghei infection on the development of liver tumors induced in male Buffalo rats by aflatoxin B 1 (AFBF). Intraperitoneal (i‐p.) injection of 10 6 parasitized red blood cells (pRBC) into the rat 12 days prior to administration of 2 ppm dietary AFB 1 for 10 weeks diminished hepatocellular carcinoma (HCC) induction compared to that observed in rats given AFB 1 alone at weeks 60–82. No animals in a control group developed HCC lesions, while only 1 of 22 rats treated With P. berghei alone developed a neoplastic nodule at week 82. These data suggest a reducing effect of P. berghei on the development of liver tumors induced by AFB 1 in male Buffalo rats. Copyright © 1988 Wiley‐Liss, Inc., A Wiley Company