Publication: Increased proportion of apoptotic cells in cat kidney tissues infected with feline morbillivirus
Issued Date
2020-01-01
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ISSN
14328798
03048608
03048608
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2-s2.0-85089828227
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Mahidol University
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SCOPUS
Bibliographic Citation
Archives of Virology. (2020)
Suggested Citation
Kripitch Sutummaporn, Kazuhiko Suzuki, Noboru Machida, Tetsuya Mizutani, Eun Sil Park, Shigeru Morikawa, Tetsuya Furuya Increased proportion of apoptotic cells in cat kidney tissues infected with feline morbillivirus. Archives of Virology. (2020). doi:10.1007/s00705-020-04782-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/59132
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Title
Increased proportion of apoptotic cells in cat kidney tissues infected with feline morbillivirus
Abstract
© 2020, Springer-Verlag GmbH Austria, part of Springer Nature. In order to study potential pathogenic mechanisms of feline morbillivirus (FeMV) in infected kidney cells, we performed a terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and an immunofluorescence assay (IFA) with an anti-FeMV P protein antibody on a total of 38 cat kidney tissues, 12 of which were positive for FeMV. Among these samples, we detected significantly larger numbers of apoptotic cells in FeMV-positive tissues than in FeMV-negative tissues, and in these tissues, a substantial percentage of TUNEL-positive (TUNEL+) cells contained the FeMV P protein (mean, 37.4; range, 17.4-82.9), suggesting that induction of apoptosis may be an important mechanism for pathological changes associated with FeMV infection in cat kidney tissues.