Publication:
Overestimating resistance in field testing of malaria parasites: Simple methods for estimating high EC<sup>50</sup> values using a Bayesian approach

Issued Date

2007-02-13

Resource Type

Article

ISSN

14752875

DOI

10.1186/1475-2875-6-4

Other identifier(s)

2-s2.0-33846863617

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Malaria Journal. Vol.6, (2007)

Suggested Citation

Kasia Stepniewska, Kesinee Chotivanich, Alan Brockman, Nicholas P J Day, Nicholas J. White Overestimating resistance in field testing of malaria parasites: Simple methods for estimating high EC<sup>50</sup> values using a Bayesian approach. Malaria Journal. Vol.6, (2007). doi:10.1186/1475-2875-6-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/24579

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Overestimating resistance in field testing of malaria parasites: Simple methods for estimating high EC<sup>50</sup> values using a Bayesian approach

Author(s)

Kasia Stepniewska
 Kesinee Chotivanich
 Alan Brockman
 Nicholas P J Day
 Nicholas J. White

Other Contributor(s)

Mahidol University
 Churchill Hospital
 Shoklo Malaria Research Unit

Abstract

Conventional methods of assessing in-vitro antimalarial drug-concentration effect relationships in field testing of fresh isolates assess each parasite isolate individually. This leads to systematic overestimation of EC50 values for the most resistant isolates, and thus overestimation of the degree of resistance. In antimalarial drug-susceptibility studies conducted on the north-western border of Thailand the overestimation of EC50 for the most resistant isolate ranged from 15% for artesunate to 43% for mefloquine. If isolates cannot be stored for re-testing, more accurate estimations of the degree of resistance can be obtained using a Bayesian approach to data analysis which is described here. © 2007 Stepniewska et al; licensee BioMed Central Ltd.

Keyword(s)

Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/24579

Collections

Scopus 2006-2010