Publication: Thunbergia laurifolia extract ameliorates cognitive and emotional deficits in olfactorectomized mice
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Issued Date
2015-08-01
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ISSN
17445116
13880209
13880209
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2-s2.0-84930795855
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Mahidol University
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SCOPUS
Bibliographic Citation
Pharmaceutical Biology. Vol.53, No.8 (2015), 1141-1148
Suggested Citation
Piyanuch Rojsanga, Pongtip Sithisarn, Ken Tanaka, Daishu Mizuki, Kinzo Matsumoto Thunbergia laurifolia extract ameliorates cognitive and emotional deficits in olfactorectomized mice. Pharmaceutical Biology. Vol.53, No.8 (2015), 1141-1148. doi:10.3109/13880209.2014.962059 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/35414
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Title
Thunbergia laurifolia extract ameliorates cognitive and emotional deficits in olfactorectomized mice
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Abstract
© 2015 Informa Healthcare USA, Inc. All rights reserved. Context: Thunbergia laurifolia Lindl. (Acanthaceae) is a Thai medicinal plant used for the detoxification of poison which is likely to be beneficial for the treatment of cognitive deficits including Alzheimer's disease. Objective: To elucidate the effects of Thunbergia laurifolia leaf extract (TLL) on cognitive dysfunction and depression-like behavior in olfactory bulbectomized mice (OBX). Materials and methods: OBX mice were treated daily with TLL at the dose of 250 and 500 mg/kg, tacrine, and imipramine, on the day after 10 d of OBX operation. The effects of TLL on cognitive and depression-like behavior of the animals were analyzed. After completing behavioral experiments, the expression levels of cholinergic marker genes encoding ChAT and muscarinic M1 receptor were quantitatively analyzed. Results: TLL and tacrine reduced OBX-induced cognitive deficits in the object recognition test (ORT) with the time spent for the novel object two times longer than that of the familiar object. Moreover, TLL at the dose of 500 mg/kg and imipramine ameliorated depression-like behavior in the tail suspension test (TST) by reducing the duration of immobility from 25.18% to 3.16% and from 25.18% to 6.48%, respectively. TLL at the dose of 250 and 500 mg/kg reversed the OBX-induced down-regulation of ChAT mRNA expression in the hippocampus from 0.12 to 0.17 and 0.24, respectively, while the down-regulation of mRNA expression of muscarinic M1 receptor was also reversed by TLL from 0.23 to 0.38 and 0.48, respectively. Conclusions: TLL ameliorates non-spatial short-term memory deficits in OBX mice, and has the potential to exhibit an antidepressant-like action.