Jaw bone regeneration in relation to position of dental implant.

Abstract

Objective: To evaluate the correlation of molecular parameters of bone cells such as BMP2, FGF23, RUNX2 from osteotomies sites and bone type according to Cone Beam Computer Tomography (CBCT), surgeon tactile sensation. Materials and methods: Study designs: Experimental cross sectional study. The bone specimens were collected during operation. The specimens were placed in refrigerator at -80°C and then extracted for RNA. The cDNA product was used for TaqMan RT-PCR reaction analysis. Results: Among total 34 implant sites, 21 (62%) were from male with mean age 51 years old. The majority of bone type was type 3+4 with 28 (82.4%) from CBCT and 22 (64.7%) from surgeon tactile, respectively. Gene expression profi le demonstrated that BMP2, FGF23, and RUNX2 were expressed; 52.9%, 23.5% and 41.2%.The gingival thickness and smoking was found signifi cantly difference with wound healing but not signifi cant difference with BMP2, FGF23 and RUNX2 gene expression (p <0.05). Conclusion: Molecular parameters such as BMP2 and FGF23 gene expression were correlated with bone quantity and quality evaluation in term of wound healing including the thickness of soft tissue and amount of hard tissue. This study suggested the possibility of osteogenic gene profi le matching the human jawbone.